Description
Ultra performance liquid chromatography - tandem mass spectrometer (UPLC-MS/MS) is a chemistry technique that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry. (UP)LC-MS/MS is a powerful technique used for many applications which has very high sensitivity and selectivity. Generally its application is oriented towards the general detection and potential identification of chemicals in the presence of other chemicals (in a complex mixture).
Shared Research Facilities has the following ULPC-MS/MS systems:
Technical Details
The technique has both qualitative and quantitative uses. These include identifying unknown compounds, determining the isotopic composition of elements in a molecule, and determining the structure of a compound by observing its fragmentation. Other uses include quantifying the amount of a compound in a sample.
Applications
These instruments can be used for different type of research, for example:
Analysis of residues of:
- hormones in animal matrices, feed and forensic samples
- veterinary drugs in animal matrices and feed
- pesticides in vegetables and fruit toxines in vegetables, fruit and cereals
- marine toxines in fish and shellfish
But also think about:
- Pharmacokinetics
- Toxicology screening and confirmation
- Contaminants
- Forensic research
Presently, the TQS is used for analysis of cephalosporines and mycotoxins. Also coccidiostats can be analysed specifically with this Xevo TQS.